Purpose: to evaluate, compare and disscuss the therapeutic efficacy of intravitreal anti- VEGF and laser photocoagulation in treatment of CSME. Material &Method:We have been selected 100 eyes of 50 patients of diabetic retinopathy with diabetic macular edema (CSME) ,out of which 26 eyes were excluded due to retinal detachment, neovascular glaucoma, complicated cataract, corneal opacity. Total 74 eyes of 37 patients has been selected for the study and divided into two groups with equal numbers of eyes. Results: In group 1 patients 92% patients attained the V.A. of 6/60 – 6/24 and V.A. with pinhole improved to 6/36-6/24 and BCVA 6/36-6/18, 8% patients which developed CSME involving centre of macula and developed contraindication to anti-VEGF ( myocardial infarction) show favourable visual outcome with V.A. 6/60-6/36 when shifted to subthreshold laser .In group 2 patients 85 % attained the V.A. of finger count 2 meter to 6/60 ,V.A. with pinhole 6/60-6/36 and BCVA 6/60-6/24, 10% of patients which were developed CSME involving centre of macula treated with subthreshold laser and attain the V.A. of 6/6/-6/36 from finger count 1meter. Conclusion:This study concluded that efficacy of intravitreal anti-VEGF in treatment of CSME is better than laser photocoagulation.