Religions are considered as independent systems; It can be influenced by neighboring cultures and practices; Historically, the religions of Hinduism and Buddhism have been influenced by each other because of their emergence in the same continent and region. Hinduism is a religious system that emerged chronologically before Buddhism and existed in the Indo-Hindu, in addition to being a religious system established in the Indo-China. They differ from the concept of God and the universe, from the understanding of life, social experiences, worship and other religious rituals. For this reason, Buddhism was influenced locally by Hinduism. This interaction may have similar spots in the two systems, but there are also aspects that make them into a separate religion. Our aim in this study is to identify these distinctions and to address the historical development and reasons of their distinction.