Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
versions View all 2 versions
addClaim

This Research product is the result of merged Research products in OpenAIRE.

You have already added 0 works in your ORCID record related to the merged Research product.
addClaim

This Research product is the result of merged Research products in OpenAIRE.

You have already added 0 works in your ORCID record related to the merged Research product.

Clopidogrel resistance in elderly hospitalized patients detected by platelet closure time

Authors: BELKACEMI Malika; SEGHIER Fatima; MERAD Yassine; BENHADDOU Abelhak Ismail; BERBER Abdellah; BENDDAOUD Larradj;

Clopidogrel resistance in elderly hospitalized patients detected by platelet closure time

Abstract

Introduction: Clopidogrel is widely used in developed and developing countries for preventing and treating atherothrombotic complications due to atherosclerosis. However, some patients show clopidogrel resistance in vitro with insufficient inhibition of platelet function. This study aimed to estimate the frequency of clopidogrel resistance in elderly patients based on the platelet closure time and to identify risk factors. Material and Methods: This cross-sectional study was carried out between December 2017 and May 2018 at the University Hospital of Sidi Bel Abbes. Platelet closure time was measured using the P2Y cartridge with the Platelet Function Analyzer (PFA). Clopidogrel non-response was defined as a P2Y platelet closure time less than 106 seconds. Results: We enrolled 73 patients aged 65 year old and over in the study. Two patients were excluded because of a hematocrit less than 25%. A total of 71 subjects was included in our analysis. The sex ratio male/female was 1.15. The frequency of clopidogrel resistance in elderly patients was 18.3%, with a 95% confidence interval CI (9.30-27.3). Among the factors examined (age, sex, body mass index, tobacco, diabetes, arterial hypertension, chronic kidney failure, dyslipidemia, personal history of myocardial infarction, clopidogrel dose, associated drugs, hyperleukocytosis), only arterial hypertension was significantly associated with in vitro clopidogrel resistance p = 0.035, OR =4.525 95% CI (1.114-18.38). Conclusion: A significant rate of elderly patients did not respond to clopidogrel, which put them at a higher risk of developing thrombo-ischemic events. Point-of-care testing can help to identify these patients who may then benefit from alternative antiplatelet therapy.

Subjects by Vocabulary

Medical Subject Headings: cardiovascular diseases

Keywords

resistance, closure time, risk factor, elderly patients, Clopidogrel

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
    OpenAIRE UsageCounts
    Usage byUsageCounts
    visibility views 20
    download downloads 28
  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
    Powered byBIP!BIP!
  • 20
    views
    28
    downloads
    Powered byOpenAIRE UsageCounts
Powered by OpenAIRE graph
Found an issue? Give us feedback
visibility
download
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
views
OpenAIRE UsageCountsViews provided by UsageCounts
downloads
OpenAIRE UsageCountsDownloads provided by UsageCounts
0
Average
Average
Average
20
28
moresidebar

Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.