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Estimation of lamotrigine in pharmaceutical preparations

descriptionPublicationkeyboard_double_arrow_right Article 30 Sep 2012 English Publisher:Zenodo

Authors: K. Sharma; S. C. Lahiri;

doi: 10.5281/zenodo.5769521 , 10.5281/zenodo.5769520

Estimation of lamotrigine in pharmaceutical preparations

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Abstract

Vivekananda Mahavidyalaya, Haripal-712 403, Hooghly, West Bengal, India E-mail : ksharma71@yahoo.co.in Central Forensic Science Laboratory, 30, Gorachand Road, Kolkata-700 014, India E-mail : suijtclahiri@yahoo.com Fax : 91-33-22849442 Manuscript received 16 June 2011, accepted 30 December 2011 Lamotrigine (LTG) is an important anticonvulsant drug used in the treatment of epilepsy and all kinds of seizures. Due to its importance, the assay of LTG in commercial tablets attracted much attention. The chloranillic acid in acetonitrile was found to be most suitable for the assay of LTG in different pharmaceutical dosage forms in a simple way, which is described in this article. The CT complex between p-chloranilic acid and lamotrigine at 521 nm was used to determine accurately the concentration of lamotrigine in tablets.

Keywords

LOQ, UV-Visible spectrophotometry, estimation, Lamitor-DT, lamez, Lamotrigine, LOD

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