Summary:Facedwith the spread of the coronavirus, the Moroccan population is in confinement, thisperiod of confinement isdifficult to live for all and especially for somevulnerable people, they are worried for theirhealth and that of theirfamilies, and theyriskhavingpsychologicalrepercussionsanxio- depressive, whichnegatively influences theirsocio-professional life. Objective: to measure the degree of depression and anxiety in the general population during a period of confinement Method: cross-sectional, descriptive and analyticalstudyconductedfrom 30 April to 10 August 2020, using a questionnaire, including the BECK scales for depression, the GAD (GeneralizedAnxietyDisorder) for anxiety Results: 632 responseswerecollected, of which 70.8% werewomen, 40.9% werebetween 18 and 30 yearsold, 47.8% were single, 76% hadhighereducation, 14.4% had a psychiatrichistory. 64.8% of the participants haddepression, of which 28.6% hadmilddepression, 24.3% hadmoderatedepression, 11.9% hadseveredepression and 8.3% hadanxiety. Age, presence of children, marital status, agreement to confinement, workduring confinement and type of occupation;presented a statisticallysignificantdifferencewith a P <0.005 between the 2 groups presenting or not a depression. Univariatelogisticregressionanalysisshowedthat the presence of anxiety (OR = 7.307; 95% CI: 2.4977 -21.379), and physicalpresence at the work site compared to the non-work group (OR = 0.5097; 95% CI: 0.2728 -0.950) wereindependentlyassociatedwith the occurrence of depression. Conclusion: Exploration of depression and anxietyconcludedthattherewas a definite impact of containment on the general population in Morocco. Research data are needed to developstrategies to reducepsychological impacts and psychiatricsymptomsduring the epidemic.