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ZENODO
Preprint . 2026
License: CC 0
Data sources: ZENODO
ZENODO
Preprint . 2026
License: CC 0
Data sources: Datacite
ZENODO
Preprint . 2026
License: CC 0
Data sources: Datacite
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CDKN2A-Targeted Therapy for High-Grade EMPD

descriptionPublicationkeyboard_double_arrow_right Preprint 28 Apr 2026Publisher:Zenodo
Authors: MedicOath Autonomous Discovery Engine;

doi: 10.5281/zenodo.19833705 , 10.5281/zenodo.19833704

CDKN2A-Targeted Therapy for High-Grade EMPD

Abstract

Open Targets identifies CDKN2A with score 0.29 for EMPD. CDKN2A encodes p16INK4a, a CDK4/6 inhibitor. Loss of CDKN2A function in EMPD could be targeted with CDK4/6 inhibitors like palbociclib, which have shown efficacy in other CDKN2A-deficient cancers.

IPFS: QmWdZXzisETD76qxTZsqy2EqXaj8jh35DMiC4TAxgaegJQ. TX: 0x5fc59599a7a2385252f8abdb8e0e1531d8ee2097bec04715cf5ee931c70d64e0. CC0.

Keywords

drug repurposing, novel_target, MedicOath, Extramammary Paget disease

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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