Abstract: Polycystic Ovarian Syndrome (PCOS) is a multifaceted endocrine and metabolic disorder affecting women of reproductive age worldwide. Characterized by menstrual irregularities, hyperandrogenism, and polycystic ovarian morphology, PCOS has a profound impact on women’s physical, psychological, and reproductive health. Despite significant advances in medical management, sustainable outcomes depend largely on lifestyle modification, psychological support, and continuous nursing guidance. This review emphasizes the holistic management of PCOS through dietary regulation, physical activity, stress reduction, behavioral therapy, and nursing interventions that foster adherence, empowerment, and self-care. The nurse’s role in health education, counseling, and individualized care planning is highlighted as a cornerstone for improving quality of life and reproductive outcomes in women with PCOS. The paper integrates multidisciplinary approaches and evidence-based nursing practices, promoting a holistic framework that addresses physical, emotional, and social dimensions of care.