ABSTRACT:The present study focuses on the formulation and evaluation of herbal lozenges usingPsidium guajava (Guava) and Jasminum grandiflorum (Chameli) leaves for the treatment ofmouth ulcers. These medicinal plants, long utilized in traditional Ayurvedic practices, are known for their rich phytochemical profiles and therapeutic properties such as anti-inflammatory, antimicrobial, and wound healing effects. Lozenges were formulated with varying concentrations of plant powders, along with other natural ingredients like tulsi,mentha, clove oil, honey, sugar, and jaggery. Phytochemical screening confirmed thepresence of alkaloids, phenolics, tannins, saponins, glycosides, and amino acids. Thelozenges underwent comprehensive evaluation for physical parameters including hardness,friability, disintegration time, moisture content, PH, and weight variation. Among the threeformulations tested, F1 and F3 showed promising results in terms of desirablephysicochemical properties and stability. This study suggests that herbal lozengesincorporating guava and chameli leaves may serve as an effective and natural therapeuticapproach for managing mouth ulcers.