The Nisti-Hasti framework introduces two fundamental components—Nisti (dynamic quantum vacuum fluctuations) and Hasti (conversion of matter into spacetime geometry)—to unify four major problems in modern physics (dark energy, dark matter, the black hole information paradox, and quantum gravity) into a single mathematical structure. The theory predicts a 25% reduction in galaxy density at high redshifts (z > 10) and a distinct gravitational wave signature (Ω_GW ∝ f^{-3/2 + 0.15}), offering a 15–20% improvement in fit to DESI, JWST, and LIGO-Virgo data compared to ΛCDM. Simulation codes and data are available on supplementary materials.