Cardiovascular disease (CVD) remains a leading cause of mortality, particularly among younger populations, necessitating advancements in surgical interventions such as coronary artery bypass grafting (CABG). This study assessed the likelihood of early postoperative complications in 121 CABG patients, categorizing them by intraoperative hemolysis (IOH) levels. Complications were observed in 23.6% of patients, with a significantly higher rate in those with severe ischemic organ damage (57.9%, p<0.001). Key predictors of complications included oxidative stress markers, free iron levels, and endothelial dysfunction. A predictive model integrating biochemical parameters such as malondialdehyde, transferrin, and nitric oxide metabolites demonstrated high sensitivity (96.5%) and specificity (100%), with an area under the ROC curve of 0.992. These findings highlight the importance of early risk assessment, oxidative stress management, and individualized treatment strategies to enhance postoperative outcomes. Future research is essential to validate and implement these predictive methods in clinical practice.