1,3,4-oxadiazoles, heterocycles bearing one oxygen and two nitrogen atoms in a five membered ring have their application in the diverse areas of medicine.[1] This interesting group of compounds has diverse biological activities such as antibacterial, antifungal, antiviral, anticonvulsant, anticancer, anti-inflammatory, anti HIV, anti-tubercular activity etc.[2] Researchers are interested in developing and studying novel heterocyclic compounds that contain 1,3,4-oxadiazole because of its many significant applications. We have attempted to provide an overview of some of the significant studies that have been recognized for the various biological activities exhibited by 1,3,4-oxadiazole derivatives.[3] These findings and our interest in pharmaceutical chemistry of heterocyclic compounds which guide us to synthesize different derivatives of 1,3,4-oxadiazole with different substitution and there pharmacological activities. This article will aid in the development of new compounds that contain 1,3,4-oxadiazole derivatives, which may be essential in the treatment of many illnesses and serve as a model medicine.[4].