Background: The 2024 monkeypox (mpox) outbreaks are characterized by significant epidemiological shifts and health impacts, particularly in the Democratic Republic of Congo (DRC) and among high-risk populations globally. The resurgence of mpox has raised concerns about its transmission dynamics and the effectiveness of public health responses. Aim: This overview will discuss the Mpox outbreak presentation, management, and prevention. Method: This is a comprehensive review COPD. The PUBMED and Google Scholar search engines were the main databases used for the search process, with articles collected up to 2016. This thorough review ensures that the information presented is reliable. Conclusion: The Mpox situation in 2024 showcases a blend of epidemiological dynamics, public health initiatives, and persistent research into prevention and treatment. Transmission remains primarily through close contact, with respiratory methods being less significant, highlighting the need for heightened public awareness, especially in non-endemic areas. To effectively manage and control monkeypox outbreaks, a comprehensive approach involving advanced diagnostic techniques, antiviral therapies, and vaccination strategies is essential, along with continuous research to adapt to evolving challenges. Keywords: monkeypox (mpox), outbreak, presentation, management, prevention.