The main objective of present work is formulation and evaluation of ketorolac mucoadhesive buccal tablets. The buccal tablets were tested for weight uniformity, thickness, friability and hardness. Tablets were then evaluated for their swelling index, in vitro drug release, muc The main objective of present work is formulation and evaluation of ketorolac mucoadhesive buccal tablets. The buccal tablets were tested for weight uniformity, thickness, friability and hardness. Tablets were then evaluated for their swelling index, in vitro drug release, mucoadhesion time (wash-off time) and ex vivo drug permeation. The kinetics and mechanism of the drug permeation through the excised buccal tissue of goat from the buccal tablets were also characterized. The data collected were then analyzed using software to determine the effects of each parameter. The effects of the various parameters involved were then interpreted. The best polymer composite was selected from the various ratios of the polymers. The mucoadhesive strength of buccal tablets increases as the concentration of secondary polymer increases. The above polymer composite had shown satisfactory results in the parameters such as thickness, hardness, drug content, swelling index, mucoadhesive time, in-vitro dissolution and in-vitro diffusion. The satisfactory formulation shows a zero order drug release profile depending on the regression value and shown a satisfactory dissolution profile. The oral cavity and its highly permeable mucosal tissues have been taken advantage for decades as a site of absorption for delivery of drugs to the systemic circulation. So the formulations which target the oral cavity through buccal mucosa are of considerable interest to improve the bioavailability and reduce the frequency of administration of APIs. Drugs administered through the buccal route have a rapid onset of action and leads to improved bioavailability of drugs. The buccal route can by pass the first-pass metabolism, by pass contact of the drugs with the gastrointestinal fluids and paves way for easy access to the membrane sites so that the delivery system can be applied, localized and removed easily. Furthermore, there is good potential for prolonged delivery through the mucosal membrane within the oral mucosal cavity. Buccal adhesive systems offer innumerable advantages in terms of accessibility, administration and withdrawal, retentivity, low enzymatic activity, economy and high patient compliance. Keywords: Drug, Evaluation, Metabolism, Bioavailability, Swelling index. oadhesion time (wash-off time) and ex vivo drug permeation. The kinetics and mechanism of the drug permeation through the excised buccal tissue of goat from the buccal tablets were also characterized. The data collected were then analyzed using software to determine the effects of each parameter. The effects of the various parameters involved were then interpreted. The best polymer composite was selected from the various ratios of the polymers. The mucoadhesive strength of buccal tablets increases as the concentration of secondary polymer increases. The above polymer composite had shown satisfactory results in the parameters such as thickness, hardness, drug content, swelling index, mucoadhesive time, in-vitro dissolution and in-vitro diffusion. The satisfactory formulation shows a zero order drug release profile depending on the regression value and shown a satisfactory dissolution profile. The oral cavity and its highly permeable mucosal tissues have been taken advantage for decades as a site of absorption for delivery of drugs to the systemic circulation. So the formulations which target the oral cavity through buccal mucosa are of considerable interest to improve the bioavailability and reduce the frequency of administration of APIs. Drugs administered through the buccal route have a rapid onset of action and leads to improved bioavailability of drugs. The buccal route can by pass the first-pass metabolism, by pass contact of the drugs with the gastrointestinal fluids and paves way for easy access to the membrane sites so that the delivery system can be applied, localized and removed easily. Furthermore, there is good potential for prolonged delivery through the mucosal membrane within the oral mucosal cavity. Buccal adhesive systems offer innumerable advantages in terms of accessibility, administration and withdrawal, retentivity, low enzymatic activity, economy and high patient compliance. Keywords: Drug, Evaluation, Metabolism, Bioavailability, Swelling index.