Looking out of Information Science (IS) it´s a dangerous attempt to compare this relative new science direct with Philosophy. Here you find a first circumspective trial of an investigation of the traditionally named “queen of science”, Philosophy, two thousand years old and - direct opposite - the only a half century old Information Science. For me it is till now not yet clear how to do this in a serious scientific manner. I worked in Applied Informatics for 30 years and make Information Science since about 15 years. Here I dare to publish for first time the results. SOKRATES (469 – 399 b.Chr.), PLATON (428/27- 348/47 b.Chr.) und ARISTOTELES (384 - 322 b.Chr.) as inventors of our traditional occidental Philosophy, have founded the search of the sense of our Human Life, Thinking and Acting as an own science. They set the Joy of Life on top of their way of thinking. PLATON has separated this special new thinking from the „Sophists“ who had a very good public image too at his time. But they were thinking more about common business facts and knowledge only. Today we would call them manufacturer, qualified skilled workers or even bachelors of special sciences. Philosophy has (since over 20 centuries) till today first of all the smart and high duty to serve Religion and Ethics as mental, spirit- and language-grounded science-base. In other direction it was used to overthink our whole surrounding nature theoretically and completely by our best Human Mind. It´s our traditional science on our mental highest level. All sciences can be related by Philosophy. That´s possible by our human ability to Learn, Think, Understand and finally Know any interesting new fact. Where and how do we have now to integrate this new own science Information Science? We search consciously term-oriented and make an abstract science-theoretical comparison to find answers and definitions.