Aim: To estimate the frequency of orthodontic anomalies in the period of mixed dentition in children, and to highlight the importance of prompt treatment in order to prevent more serious disorders of the child oral health. Materials and methods: For accomplishing the goal we’ve conducted systematic and control check-ups on children at the age of 9; 95 children from urban areas, and 68 from rural areas. Results: Of 95 analyzed children from urban areas with ethnic Macedonian population, 81 have an orthodontic anomaly. Nearly half of them i.e. 39 have mobile appliances. The most common anomaly are protrusion of teeth standing at 28.3%, a deep bite with 21% and crowding with 17.2%. Of 68 analyzed children from rural areas of ethnic Albanians, 54 have an orthodontic anomaly, while only 3 children wear mobile appliances. The most common anomalies are both crowding and maxillary protrusion of teeth with an equal 27.7%. If we compare the results: the occurrence of orthodontic anomalies is slightly higher in the Macedonian population. Conclusion: Orthodontic anomalies are diagnosed during regular systematic dental check-ups for children aged 7-13. The period of mixed dentition, which is characterized by an intense growth of the jaws, is ideal for orthodontic treatment. The parents have opportunities to inform themselves of the orthodontic anomaly of their children and promptly visit an orthodontist. With properly conducted activities on behalf of the preventive teams, we can severely decrease the percentage of children with orthodontic irregularities.