Wędrowski Mateusz, Waśniowski Paweł, Wędrowska Ewelina, Piskorska Elżbieta, Czuczejko Jolanta, Małkowski Bogdan, Zukow Walery. Synthesis and application of (18F) fluorodeoxyglucose in oncology diagnosis. Journal of Education, Health and Sport. 2017;7(12):481-500. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1164181 http://ojs.ukw.edu.pl/index.php/johs/article/view/5245 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.12.2017. Revised: 15.12.2017. Accepted: 31.12.2017. Synthesis and application of (18F) fluorodeoxyglucose in oncology diagnosis Mateusz Wędrowski1,2, Paweł Waśniowski3,2, Ewelina Wędrowska4, Elżbieta Piskorska5, Jolanta Czuczejko2, Bogdan Małkowski1,2, Walery Zukow6 1Department of Positron Emission Tomography and Molecular Diagnostics, Nicolaus Copernicus University Collegium Medicum, Bydgoszcz, Poland 2Nuclear Medicine Department, Oncology Centre, Bydgoszcz, Poland 3Department of Inorganic and Analytical Chemistry, Nicolaus Copernicus University Collegium Medicum, Bydgoszcz, Poland 4Department of Gene Therapy, Faculty of Medicine, Nicolaus Copernicus University Collegium Medicum, Bydgoszcz, Poland 5Department of Pathobiochemistry and Clinical Chemistry, Nicolaus Copernicus University Collegium Medicum, Bydgoszcz, Poland 6Faculty of Earth Sciences, Nicolaus Copernicus University, Toruń, Poland Corresponding author: Ewelina Wędrowska Zakład Genoterapii Collegium Medicum UMK 85-094 Bydgoszcz, ul. M. Skłodowskiej-Curie 9 tel. +48 517-545-893 e-mail: ewelina.wedrowska@gmail.com Abstract [18F] Fluorodeoxyglucose ([18F] FDG) is the most commonly used radiopharmaceutical in clinical positron emission tomography (PET) in oncology. Cancer cells create their own specific microenvironment to survive and grow. Specific tumor microenvironment contributes to cancer metabolic reprogramming. Therefore, even with sufficient oxygen availability, cancer cells choose anaerobic glycolysis. Cancer cells compensate less energy efficient process by increasing the intensity of anaerobic glycolysis. Tumor cells have a high rate of metabolism and because of this, they take up more of the radioactive glucose (FDG). This makes the tumor cells appear more visible than other areas on the PET scan pictures. This paper presents nucleophilic synthesis of the [18F] FDG marker and basics of tumor development which can affect the [18F] FDG biochemical significance. Reference was made to clinical images obtained in PET technology using the [18F] FDG radiopharmaceutical. Key words: synthesis [18F] FDG, glucose metabolism, [18F] FDG metabolism, positron emission tomography.