The importance of identifying effective ways of dealing with endogenous intoxication in Lymphoproliferative disorders is acknowledged. Proper nutrition helps fight infection and provides the body with a sufficient amount of energy. For centuries, burdock root has been used for cleansing and detoxifying. In this study, we assessed the efficacy of two biologically active food supplements with nutrient-rich burdock root extract in combined therapy for LPDs. For the trial, people with stages II-IV non-Hodgkin lymphomas or with stages II-III multiple myeloma were selected. The participants were divided equally into two groups: the main group and the comparison group. The participants for both groups possessed similar characteristics and clinical data. The participants of the main group were prescribed to take supplements with concentrated burdock root extract between three treatment cycles of polychemotherapy. The supplements with burdock root extract were found to significantly reduce the severity of endogenous intoxication and improve the tolerability of systemic chemotherapy.