Aim and Background: Love is one of the most amazing emotions a person can experience and emotional failure is one of the most painful problems that can happen to anyone during a romantic relationship. The purpose of this study was to determine the effectiveness of hypnotherapy on positive and negative affect and self-efficacy of women with a history of emotional failure. Methods and Materials: The present study is of quasi-experimental with design pre-test, post-test and follow up with the control group. The statistical population included all women referring to counseling centers in Amol city with a history of emotional failure in 2017. 30 subjects were selected by available sampling method and randomly assigned to intervention and control groups. In order to conduct the research, Ross's emotional injury (1999), Panas Positive and Negative Affect Scale (PANAS) (1988) and self-efficacy questionnairs (Shaurzerz and Grosselm, 1995) were used. The experimental group received hypnotherapy for 8 sessions of 2 hours weekly. The research findings were analyzed using repeated measures analysis of variance and Bonferroni post hoc in SPSS software. Findings: The results of repeated ANOVA test showed that 8 sessions of hypnotherapy training significantly increased the positive affect (p<0.001) and self- efficacy (p<0.001) but decreased the negative effect (p<0.001) in the experimental group to the control group that showed a significant effect of hypnotherapy on the recovery of people with a history of emotional failure. Conclusions: According to research findings, hypnotherapy can be used to improve the quality of life and increase hope for the future in people with a history of emotional failure.