Twelve new locally defined case definitions were added to NC DETECT in May and June 2014 to facilitate timely surveillance for poisoning and overdose in North Carolina. The case definitions cover acute alcohol poisoning, poisoning, unintentional poisoning, heroin overdose, medication or drug overdose, methadone overdose, opioid overdose, prescription opioid analgesic overdose, Narcan/naloxone, and unintentional medication or drug overdose. Authorized users can monitor trends and review line listing details for their jurisdictions and compare their counties at the aggregate level to other counties and the state.