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Revista Colombiana de Hematología y Oncología
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Revista Colombiana de Hematología y Oncología
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Revista Colombiana de Hematología y Oncología
Article . 2020 . Peer-reviewed
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Revista Colombiana de Hematología y Oncología
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Relación neutrófilos/linfocitos en tumores sólidos.

Authors: Jorge I. López; Giovanny M. Caicedo; Margarita Velasco; Lisbeth P. Ramírez; Luis F. Cárdenas; Juan M. Herrera; Eliana Ocampo Toro; +1 Authors

Relación neutrófilos/linfocitos en tumores sólidos.

Abstract

Introducción: la asociación cáncer e inflamación ha despertado gran interés en los últimos años. Larelación neutrófilos/linfocitos (NLR) se ha utilizado como valor pronóstico y de desenlace clínico en algunostumores sólidos.Objetivo: evaluar la NLR elevada (>2,5) con el estadio clínico, metástasis y demás marcadores de severidaden pacientes con tumores sólidos.Materiales y métodos: estudio transversal analítico que incluyó 170 historias clínicas de pacientes noexpuestos a quimioterapia al diagnóstico con tumores sólidos, describiendo características clínicas y laasociación de la NLR con el estadio clínico, tipo histológico, grado de diferenciación, perfil molecular ometástasis, con prueba Chi-cuadrado y test exacto de Fisher.Resultados: el 76% femenino, mediana de 63 años, cáncer de mama 61,1%, próstata 12,3%, colon15,8%, pulmón 5,88% y ovario 4,7%. La NLR >2,5 se asoció con estadio avanzado de enfermedad (III yIV) OR 6,38 (IC95% 1,67-24,4) p = 0,007 y OR 4,6 (IC95% 1,13-19) p = 0,033, respectivamente, tumoresmal diferenciados OR 2,91 (IC95% 1,01-4,5) p = 0,046 y metástasis visceral OR 4,7 (IC95% 2,2-9,9) p =0,000. No se encontró asociación entre el NLR y el tipo histológico, perfil molecular en cáncer de mama,escala de Gleason en cáncer de próstata, ni en metástasis óseas.Conclusiones: el radio neutrófilos/linfocitos elevado es de valor, ya que se asoció en este estudio conestadio avanzado de enfermedad, tumores mal diferenciados y metástasis visceral. Se requiere ampliarla muestra con el fin de confirmar estos resultados, y, en el futuro, realizar estudios que se relacionencon eficacia terapéutica.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
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