Working in a laboratory is very difficult and needs special attention. Laboratory workers can be exposed to numerous potential hazards including chemical, biological, physical, and radioactive. That is why it is really important to follow the working principles in laboratories for the sake of the lab analyzers and others who work with them in the lab. Laboratory safety includes the use of certain laboratory rules, methods, infrastructures, and devices during work to protect the working person and the working material. All studies show that > 70% of medical decisions are based on laboratory results. In such important laboratories, it is must to get safe and reliable results. This requires a well-established working system and strict observance of laboratory safety. Biosafety is very important in parasitology laboratories as well as in all microbiology laboratories. Usually, it takes a long time for people to detect parasitic diseases through laboratory accidents, who are working in laboratories. That is why, especially in parasitology laboratories, the issue of laboratory safety should be emphasized more sensitively. We will be reviewing the hazards, parasites, exposure routes, and protective measures imposed in parasitology laboratories.