This study presents the most extensive performance comparison of pansharpening methodologies by considering 17 pansharpening algorithms that are applied to the satellite images obtained from RASAT, which is the first earth observation satellite designed and manufactured in Turkey. Standard and state-of-the-art pansharpening approaches from various categories, such as component substitution (CS), modulation based (MB), multiresolution analysis (MRA), and hybrid and variational methods, are included in order to gain a better insight and perform a thorough analysis of the performance of various pansharpening methods. The experimental validation procedure was designed according to Wald's protocol, and the performance evaluations were conducted both qualitatively and quantitatively on the basis of seven quantitative evaluation criteria.