Dental caries is one of the most common oral diseases. It is always better to prevent the disease before it advances which may result in pain, an unaesthetic look, and difficulty in mastication and function. The application of silver diamine fluoride is one of the preventive measures performed by the dentist to prevent and arrest initial dental caries. It is very effective in all age groups especially in pediatric patients. Knowledge about the exact mechanism of action of silver diamine fluoride and its method of use is a primary requirement for the dental professional. The present article emphasizes a detailed review on silver diamine fluoride. Cite this article as: Bhat Y, Babaji P, Kamalaksharappa SK, Chandrappa MP, Ambareen Z. Silver diamine fluoride: A literature review. Essent Dent. 2023;2(1):20-24.