This study arises due to the environmental pollution crisis in the El Cerrón Grande Wetland, which affects the ecological quality of the reservoir, as well as the ecosystem services that the wetland can offer. One of the common pollution problems faced by wetlands is the eutrophication of their waters, generating proliferations of phytoplankton that can reach dangerous levels. Chlorophyll-a concentration is an indirect measure of the phytoplankton biomass in a body of water [1]. The objective was to estimate the value of the concentration of chlorophyll-a through empirical models; To do this, bands from the Sentinel-2A satellite were used to provide an alternative to the most widely used index called TBDO (Triple Band Dall’ Olmo). Indices were generated with all possible combinations of the bands; furthermore, by means of principal component analysis, the bands and chlorophyll-a were grouped into three factors that were similar to the bands used by the TBDO. As a result, 3 models of 100,000 generated possibilities were chosen, which when compared against the TBDO offer a better estimate of the concentration of chlorophyll-a in the Wetland. Most of the assumptions of the models were overcome and the spatial autocorrelation was analyzed.