The genetic code may be generated using the Residue Number System (RNS). This achievement demonstrates the viability of protein synthesis. The genetic codes occupy RNS digits and enable sequence comparison as well as further analysis of biological flaws known as mutations. In this research work two mRNA reading frames (strings) are considered as strings of RNS digits. Triplets of these residue number digits constitutes an amino acids and chains of these triplets make up polypeptides, proteins. These digits are compared and single digits errors introduced, these errors mimic biological errors (mutations). The types of errors (mutations) that are manifested between the two reading frames, original and mutant, are detected and reported.