Objective: Goose immunoglobulin Y (IgY)-Fc fragment gene is cloned. Material and methods: In order to obtain a certain length (106 bp) of constant domain gene, a pair of primer was designed according to the conserved nucleotide sequence of duck (CAA46322) and chick en (S00390) IgY-Fc fragment that was published by the GenBank. Special primers were designed by the Race method to amplify the 3' terminal cDNA. Results: Goose IgY heavy chain C domain partially unknown gene is successfully cloned, and it is 782bp. The full-length gene covers the C υ3 and C υ4 domains, i.e. Fc gene encoding 202 amino acids, the predicted molecular mass of Fc gene is 22.32 kDa. The deduced amino acid sequence of goose Fc showed 89.6% and 65.3% identity with those of duck and chicken, respectively. Conclusions: Conserved sequence amplification PCR combined with Race is effective in searching and isolating Fc gene of goose. It is successfully submitted to the GenBank; GenBank accession num ber is KC254644. The structure of goose IgY-Fc was analyzed using bioinformatics tools. In the 3D structure of goose IgY-Fc, the sequence identity is 64.29% to the template (chicken: 2w59A).