Study on recombinant BCG to prevent infections of intracellular pathogens.
Copyright policy )Study on recombinant BCG to prevent infections of intracellular pathogens.
Studies on recombinant BCG (rBCG) which my group carried out so far were reviewed. Recombinant BCG which secreted alpha antigen-fused foreign antigen was constructed and tested for its ability to induce protective immunity. Thus, rBCG secreting merozoite surface protein 1 (MSP1) of Plasmodium yoelii efficiently protected the infection more than recombinant MSP 1 mixed with artificial adjuvant RAS or IFA did. rBCG which secreted excess amounts of antigen 85 complex A inhibited the multiplication of M. leprae in the footpads of mice. rBCG which secreted alpha antigen-fused IL-2 stimulated peritoneal exudate cells of mice resulting in enhancing killing a bladder cancer cell line in vitro.
- Nagasaki University Japan
- Nagasaki University Japan
Antigens, Bacterial, recombinant BCG, Mycobacterium bovis, Recombinant Proteins, GTP Phosphohydrolases, リコンビナントBCG, Mycobacterium leprae, Mice, Urinary Bladder Neoplasms, ワクチン, BCG Vaccine, Animals, Tuberculosis, Vaccine, Merozoite Surface Protein 1
Antigens, Bacterial, recombinant BCG, Mycobacterium bovis, Recombinant Proteins, GTP Phosphohydrolases, リコンビナントBCG, Mycobacterium leprae, Mice, Urinary Bladder Neoplasms, ワクチン, BCG Vaccine, Animals, Tuberculosis, Vaccine, Merozoite Surface Protein 1
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