Study on recombinant BCG to prevent infections of intracellular pathogens.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2000 English Publisher:Japanese Leprosy AssociationJournal:Japanese journal of leprosy, volume 69, pages 71-75 (issn: 1342-3681, eissn: 1884-314X,

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Authors: Y, Takeshi;

doi: 10.5025/hansen.69.71

pmid: 10979272

Study on recombinant BCG to prevent infections of intracellular pathogens.

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Abstract

Studies on recombinant BCG (rBCG) which my group carried out so far were reviewed. Recombinant BCG which secreted alpha antigen-fused foreign antigen was constructed and tested for its ability to induce protective immunity. Thus, rBCG secreting merozoite surface protein 1 (MSP1) of Plasmodium yoelii efficiently protected the infection more than recombinant MSP 1 mixed with artificial adjuvant RAS or IFA did. rBCG which secreted excess amounts of antigen 85 complex A inhibited the multiplication of M. leprae in the footpads of mice. rBCG which secreted alpha antigen-fused IL-2 stimulated peritoneal exudate cells of mice resulting in enhancing killing a bladder cancer cell line in vitro.

Related Organizations

Nagasaki University
Japan
Nagasaki University
Japan

Keywords

Antigens, Bacterial, Mycobacterium bovis, Recombinant Proteins, GTP Phosphohydrolases, Mycobacterium leprae, Mice, Urinary Bladder Neoplasms, BCG Vaccine, Animals, Tuberculosis, Merozoite Surface Protein 1

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