Towards Selective Inhibitors of Janus Kinase 3: Identification of a Novel Structural Variation between Janus Kinases 2 and 3

descriptionPublicationkeyboard_double_arrow_right Article 20 Dec 2012 English Publisher:Korean Chemical SocietyJournal:Bulletin of the Korean Chemical Society, volume 33, pages 4,207-4,210 (issn: 0253-2964,

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Authors: Mi Kyoung Kim; Youhoon Chong;

doi: 10.5012/bkcs.2012.33.12.4207

Towards Selective Inhibitors of Janus Kinase 3: Identification of a Novel Structural Variation between Janus Kinases 2 and 3

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Abstract

E-mail: chongy@konkuk.ac.krReceived August 13, 2012, Accepted September 6, 2012Key Words : Janus kinase 3 (JAK3), Selective inhibitors, Flavonoid conjugate, Structural variationThe mammalian Janus kinase (JAK) family of intracellularnonreceptor protein tyrosine kinases consists of four iso-forms (JAK1, JAK2, JAK3 and TYK2) that play key roles inthe cytokine-mediated JAK-STAT (signal transducer andactivator of transcription) signaling pathway which controlssurvival, proliferation, and differentiation of a variety ofcells.

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Konkuk University
Korea (Republic of)

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