Acquired coagulation inhibitors are rare but acquired bleeding diathesis caused by autoimmune depletion or dysfunction of coagulation factors can be life-threatening. This occurs most frequently in elderly patients who lack disease associations. Acquired coagulation inhibitors may also arise in association with systemic lupus erythematosus (SLE). The groups of patients who suffer from SLE most frequently are women in their 2nd to 4th decade. In this case, we present a 22-year-old man with systemic lupus erythematosus who developed an acquired inhibitory to factor II, VIII, IX, X and von Willebrand factor (vWF).