Beating the Earth's day-night cycle is mandatory for long and continuous time-series photometry and had been achieved with either large ground-based networks of observatories at different geographic longitudes or when conducted from space. A third possibility is offered by a polar location with astronomically-qualified site characteristics. Aims. In this paper, we present the first scientific stellar time-series optical photometry from Dome C in Antarctica and analyze approximately 13,000 CCD frames taken in July 2007. We conclude that high-precision CCD photometry with exceptional time coverage and cadence can be obtained at Dome C in Antarctica and be successfully used for time-series astrophysics.

accepted for A&A