Manzikert, located in the southern regions of Armenia, has consistently held a significant place in the literature of various communities from ancient times to the medieval period. This importance is attributed to the multidimensional nature of Manzikert from geographical, political, and religious perspectives, as well as its comprehensive influence on the surrounding historical trajectory. The geographical analysis of the region encompasses the etymological extensions of names, revealing the linguistic complexity that has influenced the various ways Manzikert is named in Armenian texts, primarily as Taron. From a political standpoint, the history of Manzikert unfolds through the region’s feudal structure and the power balance between dominant forces such as Rome and Iran. The rise and fall of powerful feudal families, especially the Manawazean and Mamikonean dynasties, have shaped the political landscape of Manzikert. Undoubtedly, the significance of the city transcends the political realm; Manzikert embodies a centre for cultural and religious interactions between Armenian and Syriac traditions. This region emerges as a crucial centre for the south-to-north spread of Christianity in Armenia. Therefore, the aim of this study is not only to understand the political importance of Manzikert but also to explore its religious significance and discuss its relationship with Armenian Christianity.