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Adverse events of PARP inhibitors

Authors: Jaroslav Klát; Martina Romanová;

Adverse events of PARP inhibitors

Abstract

An evaluation of the safety of poly-ADP-ribose-polymerase inhibitors (PARPi) in ovarian cancer treatment.An analysis of the studies on PARP inhibitors, a summary of the most common and serious adverse events.According to the studies, the most common adverse events of PARPi include hematotoxicity, nausea and vomiting. Serious adverse events leading to dose reduction or treatment interruption or termination include anemia, thrombocytopenia, nausea, fatigue and hypertension.According to the results of the recent studies, the treatment of ovarian cancer with PARP inhibitors is generally safe.

Keywords

Ovarian Neoplasms, Vomiting, Humans, Female, Nausea, Carcinoma, Ovarian Epithelial, Poly(ADP-ribose) Polymerase Inhibitors

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    3
    popularity
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    influence
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
3
Average
Average
Average
Related to Research communities
Cancer Research
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