This study investigates the impact of the Human Capital Index (HCI) on economic growth (EG) in Ghana, Kenya, and Tanzania using various statistical techniques. The results indicate that the relationship between HCI and EG is complex and varies by country. The coefficient for TZA is positive, while GHA and KE are negative. However, these coefficients are not statistically significant, and the overall coefficient for all countries is negative and not statistically significant. This suggests that other factors such as investment in infrastructure, education, and innovation may contribute to EG. Policymakers should consider a range of factors beyond HCI when formulating policies to promote EG in these countries. Further research is necessary to identify potential predictors of EG and explore the relationships among these factors in more detail.