Aims: To evaluate the diagnostic significance of the glucose/lymphocyte ratio (GLR) of preterm premature rupture of membranes (PPROM) and its prognostic ability in predicting adverse neonatal outcomes. Methods: A retrospective assessment was performed on 321 pregnant women who delivered at a tertiary center between January 2023 and January 2025. The study included 156 women diagnosed with PPROM at a gestational age of ≤34+6 weeks. The control group comprised 165 women without PPROM, matched for maternal age, body-mass index (BMI) and gestational week. A poor prognosis was defined as neonatal intensive care unit (NICU) admission, 5-minute APGAR score 0.05). GLR values remained consistent across latency periods (