The availability of multidisciplinary and high-resolution data is a fundamental requirement to understand the physics of earthquakes and faulting. We present the Alto Tiberina Near Fault Observatory (TABOO), a research infrastructure devoted to studying preparatory processes, slow and fast deformation along a fault system located in the upper Tiber Valley (northern Apennines), dominated by a 60 km long low-angle normal fault (Alto Tiberina, ATF) active since the Quaternary. TABOO consists of 50 permanent seismic stations covering an area of 120 × 120 km2. The surface seismic stations are equipped with 3-components seismometers, one third of them hosting accelerometers. We instrumented three shallow (250 m) boreholes with seismometers, creating a 3-dimensional antenna for studying micro-earthquakes sources (detection threshold is ML 0.5) and detecting transient signals. 24 of these sites are equipped with continuous geodetic GPS, forming two transects across the fault system. Geochemical and electromagnetic stations have been also deployed in the study area. In 36 months TABOO recorded 19,422 events with ML ≤ 3.8 corresponding to 23.36e-04 events per day per squared kilometres; one of the highest seismicity rate value observed in Italy. Seismicity distribution images the geometry of the ATF and its antithetic/synthetic structures located in the hanging-wall. TABOO can allow us to understand the seismogenic potential of the ATF and therefore contribute to the seismic hazard assessment of the area. The collected information on the geometry and deformation style of the fault will be used to elaborate ground shaking scenarios adopting diverse slip distributions and rupture directivity models.