This chapter focuses on the importance of the impact of e-commerce and digital technologies in the transition from the European single market into a Digital Single Market (DSM). Highlighted is the opportunity that this change may present to enable the growth of the European Union’s international trade by capitalising on the potential of electronic transactions to enhance trust within the European digital framework. Key issues of data protection and data localization – the former leading to trust, while the latter causes fragmentation – and the importance of data security for trust and the interoperability of data flows under the DSM are analysed.