Hepatitis C virus (HCV) infection is a health problem involving more than 100 million people worldwide. However, despite these high numbers, only a group of infected people will develop serious difficulties from viral persistence. Liver fibrosis is the main complication of chronic HCV infection, and its eventual outcome –liver cirrhosis– is responsible for liver-related morbidity and mortality (1). The progression rate of fibrosis varies a lot amongst individuals, and its acknowledgment is a determining factor for the assessment of prognosis and treatment needs. Therefore, the search for predictive factors associated with poorer outcome is an interesting work field for the management of these patients.