This paper examines the nature of initial neolithisation indications during the terminal Pleistocene and earliest Holocene in the Southern Levant. This interval corresponds to a period of significant and geographically variable environmental changes in the region. Various lines of evidence are provided to demonstrate the long durée (c. 15 000 years) character of interactions during the Early, Middle and Late Epipalaeolithic that were instrumental to the emergence of the fullyfledged agricultural life ways in the later phases of the Early Neolithic (PPNB).