Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous rash characterized by the abrupt onset of a widespread generalized pustular rash often accompanied by fever. In the etiopathogenesis, there is a history of drug use in 90% of the cases, and occasionally hypersensitivity reactions to mercury or viral and bacterial infections are accused. Nonfollicular eruptions on a erythematous surface spreading on a large scale are clinical features. There is no specific treatment when underlying cause cured spontaneous healing occures. AGEP’s etiology clinical and histopathologic characteristics are reviewed here. (Journal of Current Pediatrics 2013;11:77-80)