<div class="htmlview paragraph">The design of 4-stroke engines, complying with the new Motorcycle Road Racing World Championship regulations is discussed. Similarity rules and non dimensional parameters from a database on racing engines are used to define some general guidelines. More specific information about friction losses and combustion is derived from experiments, carried out on a 3-cylinder MotoGP prototype engine. These experiments provided the input needed to set up and validate a base model for 1D thermo-fluid-dynamic calculations. Engine simulation is employed for optimizing several design parameters. A comparison between the proposed methodology and a few design criteria presented in literature is made. Finally, the brake performances of some optimized engines are predicted.</div>