PCSK1 (proprotein convertase subtilisin/kexin type 1)

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2018 France Publisher:INIST-CNRSJournal:Atlas of Genetics and Cytogenetics in Oncology and Haematology (eissn: 1768-3262,

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Authors: Demoures, Béatrice; Siegfried, Géraldine; Khatib, Abdel-Majid;

doi: 10.4267/2042/68910

handle: 2042/68910

PCSK1 (proprotein convertase subtilisin/kexin type 1)

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Abstract

PCSK1 is a serine protease involved in the proteolytic processing of a variety of protein precursors mainly neuropeptides and prohormones. In 1991, PC1/3; also known as PCSK1, PC1, PC3, and SPC3 was identified at the same time by two laboratories separately. The human and mouse PCSK1 genes are localized on chromosomes 5 and 13, respectively. The cleavage of these protein precursors is required for the mediation of their functions including the regulation of glucose homeostasis and food intake.

Country

France

Related Organizations

Institut de lInformation Scientifique et Technique du CNRS
France

Keywords

PC1, PCSK1, cancer, chromosome 5, endocrine disorders, Genes Section

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