Large plane displays are often achieved by combining tiled imaging elements, which give the appearance of a single, seamless display. However, this is difficult to realize in practical use, since differences in color will make the tiles dis-tinct even if the geometric calibration is perfect. The paper presents an approach of color calibration using cubic B- spline. According to the theory of cubic B-spline, we construct the color transfer function of each projector. This ap-proach reduces the color and photometric non-uniformities to achieve seamless tiled multi-projector display well. Finally, we propose the difference between blending region and overlapping region which can help to achieve a better effect of alpha blending.