By the explosive growth of B2B e-commerce transactions in international supply chains and the rapid increase of business documents in Iran’s cross-border trading, effective management of trade processes over borders is vital in B2B e-commerce systems. Structure of the localized model in this paper is based on three major layers of a B2B e-commerce infrastructure, which are messaging layer, business process layer and content layer. For each of these layers proper standards and solutions are chosen due to Iran’s e-commerce requirements. As it is needed to move smoothly towards electronic documents in Iran, UNedocs standard is suggested to support the contents of both paper and electronic documents. The verification of the suggested model is done by presenting a four phase scenario through case study method. The localized model in this paper tries to make a strategic view of business documents exchange in trade processes, and getting closer to the key target of regional single windows establishment in global trade e-supply chains.