The paper considers the different conceptual frameworks which enact the structural problem and lead to making sense of the results obtained from structural analysis. In fact, there are strong connections between how one frames a problem and what is then searched and solved. While the technical aspects, like mechanical nonlinearities or stochastic uncertainties, are considered today scholars have already developed and almost transparently controlled these aspects. There are a number of human related factors that must be recognized and faced to have a realistic, i.e. useful or more generally ecologically effective, picture of the structure being studied. It seems that the journey in this broad context is just at the beginning.