This paper summarizes the main results of the Italian project “Comfort Tecnologico”, that was granted a subvention by the HI TEX pilot Program 2007/2008 managed by Tuscany regional authority Regione Toscana. The “Comfort Tecnologico” Project goal is to combine fine natural fibers (such as cashmere, alpaca, mohair and wool, pure or mixed) with different types of metals yarns to create new category of fabrics and garments with high comfort characteristics. Different tests have been performed on several samples of different materials and results have been compared. Copper and cashmere turned out as the most promising combination in terms of improved characteristics of the newly created yarns and textiles. At the end, some remarks and perspectives regarding future development have been addressed.