Alopecia areata (AA) is a chronic, immune-mediated, non-scarring alopecia that causes patches of hair loss, typically on the scalp and face. Alopecia universalis (AU) is a severe form of AA that involves complete hair loss on the scalp and body. Although the genetics and immune pathogenesis have been recently better described, the exact cause and effective therapies remain unclear. We describe a case of a man with long-standing AU that regrew hair after supplementation with testosterone, chorionic gonadotropin (hCG) and DHEA-S.