Infectious complications in Gynecology Oncology surgical procedures are related with significant morbidity and potential mortality. Several infectious complications may be confronted in gynecology oncology practice and these encompass intra abdominal infections, infections of the vaginal cuff, endometritis, wound infections, subcutaneous cellulitis, perineal infections, port site infections in laparoscopic and endoscopic interventions, cystitis etc. The hospitalization of the patient is prolonged and the health care costs are increased hence causing alertness to health trust services. Since the initiation of the antibiotic era administration, an enormous amount of studies and trials have been conducted leading the clinician to uncertainties which regimen to apply, what dose to give, when to give and for how long?