Caspase-11, the Main Executioner in Non-canonical Inflammasome

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2012 English Publisher:The Korean Society for Microbiology and The Korean Society of VirologyJournal:Journal of Bacteriology and Virology, volume 42, page 169 (issn: 1598-2467, eissn: 2093-0429,

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Authors: Zahid Manzoor; Young-Sang Koh;

doi: 10.4167/jbv.2012.42.2.169

Caspase-11, the Main Executioner in Non-canonical Inflammasome

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Abstract

Murine caspase-11 is orthologus to human caspase-4 and caspase-5, and is required for the response to cholera toxin B and infection with Escherichia coli, Citrobacter rodentium or Vibrio cholerae. Caspase-11 rather than caspase-1 is the main offender involved in sepsis. Hence, caspase-11 plays an essential pro-inflammatory role in innate immune response to bacterial infections.

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Jeju National University
Korea (Republic of)

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