Virus infections in tumors pave the way for tumor-directed DC-vaccines

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Mar 2012 English Publisher:Informa UK LimitedJournal:OncoImmunology, volume 1, pages 208-210 (eissn: 2162-402X,

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Authors: Woller, Norman; Kühnel, Florian; Kubicka, Stefan;

doi: 10.4161/onci.1.2.18099

pmid: 22720244

pmc: PMC3377008

Virus infections in tumors pave the way for tumor-directed DC-vaccines

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Abstract

Effective treatment of solid cancers by tumor-directed DC-vaccines still remains a challenge in clinical oncology. For therapeutic success, knock-down of tumor-specific tolerance appears mandatory before a potent tumor-specific cytotoxic T-cell response can be triggered by DC-vaccinations. Evidence is emerging that lytic virus infection in tumors can provide valuable help.

Related Organizations

Kreiskliniken Reutlingen
Germany
Hannover Medical School
Germany

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