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mAbs
Article . 2014 . Peer-reviewed
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mAbs
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mAbs
Article . 2015
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https://dx.doi.org/10.4161/mab...
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Claim

Discovery and characterization of olokizumab

A humanized antibody targeting interleukin-6 and neutralizing gp130-signaling
descriptionPublicationkeyboard_double_arrow_right Article 02 Apr 2014 English Publisher:Informa UK LimitedJournal:mAbs, volume 6, pages 773-781 (issn: 1942-0870, eissn: 1942-0862, Copyright policy )
Authors: Shaw, Stevan; Bourne, Tim; Meier, Chris; Carrington, Bruce; Gelinas, Rich; Henry, Alistair; Popplewell, Andrew; +7 Authors

doi: 10.4161/mabs.28612

pmid: 24670876

pmc: PMC4011921

Discovery and characterization of olokizumab

Abstract

Interleukin-6 (IL-6) is a critical regulator of the immune system and has been widely implicated in autoimmune disease. Here, we describe the discovery and characterization of olokizumab, a humanized antibody to IL-6. Data from structural biology, cell biology and primate pharmacology demonstrate the therapeutic potential of targeting IL-6 at "Site 3", blocking the interaction with the signaling co-receptor gp130.

Related Organizations
Keywords

Models, Molecular, Binding Sites, Hybridomas, Sequence Homology, Amino Acid, Interleukin-6, Molecular Sequence Data, Antigen-Antibody Complex, Antibodies, Monoclonal, Humanized, Crystallography, X-Ray, Antibodies, Neutralizing, Arthritis, Experimental, Rats, Immunoglobulin Fab Fragments, Macaca fascicularis, Report, Interleukin-6 Inhibitors, Cytokine Receptor gp130, Animals, Humans, Female, Amino Acid Sequence

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 82
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
82
Top 1%
Top 10%
Top 10%
Green
gold